Neurodevelopment. Congenital heart disease (CHD) refers to a broad group of structural abnormalities of the heart that are present at birth and affect approximately 1% of all live births. Over the past two decades, advances in neonatal surgery and perioperative care have dramatically increased survival rates. Yet this success has revealed an important challenge, and focus has gradually shifted from the heart alone to the brain. A growing body of evidence has shown that children with CHD are at increased risk for neurodevelopmental disorders, including delayed language acquisition, executive dysfunction, and visuospatial processing difficulties. In a recent publication, we took advantage of a unique biorepository to explore how early differences can be identified on the molecular level that may inform later neurodevelopmental features. Here is what we found.